P53 activates the long noncoding rna pvt1b to inhibit myc and suppress tumorigenesis. Discussing pericentromeric long noncoding RNAs at UCLA .

P53 activates the long noncoding rna pvt1b to inhibit myc and suppress tumorigenesis Cori presents poster on p53 and Dicer in oncogene-induced senescence at University of California, Riverside . 014. Cell (2020) M. Overview of attention for article published in Molecular Cell, February 2020. . The PVT1 expression level was measured in 64 FFPE TC paired samples by real-time quantitative PCR. Cowell et al. Over-activation of MYC activates the ARF and p53 checkpoints resulting in cell death or arrest, while ARF can inhibit MYC function. Molecular Cell 2020 | Journal article DOI: 10. We aimed to explore the PVT1 and four apoptosis-related proteins (p53, Bcl2, and PD-1/PD-L1) signature in thyroid cancer (TC). Downstream Wang LY, Yu YL, Chen HW, Srivastava S, Petrovics G, et al. Olivero, Elena Martínez-Terroba, Joshua Zimmer, Clara Liao, Ephrath Tesfaye, Nima Hooshdaran, Jeremy A. Mol Cell 2020; Noncoding RNA Res. PMID: 27147088 p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. 0-85079387608. A. 2016;35(33):4399–4406. (Link opens in a new window) PubMed p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Christiane E. Plasmacytoma variant translocation 1 (PVT1) mainly encodes a long non-coding RNA (lncRNA) and is located on chromosome 8q24. Cell. The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating Article Title: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis Journal: Molecular cell doi: 10. use biochemical and genomic methods to show that MYC-topoisome overactivity directly and acutely damages DNA, triggering MYC degradation, p53 induction, and p53-TOP1-TOP2 topoisome formation that, in turn, increases p53-target-gene expression, including TDP1 and TDP2, which help to repair topoisomerase-mediated DNA damage. Citation Report 2 # Article IF Citations 1 LncRNA PVT1 regulates p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. CE Olivero, E Martínez-Terroba, J Zimmer, C Liao, E Tesfaye, Molecular cell 77 (4), 761-774. e8. Long noncoding RNAs in cancer pathways. p53 activates the Long noncoding RNA Pvt1b to. Read more related scholarly scientific articles and p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Molecular Cell 77, 761-774. Simon, Jesse R. Molecular cell. e8 DOI: 10. Chang WM, Chang YC, Yang YC, Lin SK, Chang PMH, Hsiao M. inhibit Myc and suppress tumorigenesis. Min, J. 014 p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Zamudio,3 and Nadya Dimitrova1 ,4 * 1Department of Molecular, The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. Oncogene. January 2019 · SSRN Electronic Journal. p53 Activates the Long Noncoding RNA Pvt1b to Functional investigation of the contributions of p53-induced lncRNAs to p53-dependent outcomes highlighted Pvt1b, the p53-dependent isoform of Pvt1, as a mediator of p53-dependent senescence via Myc repression. Altmetric Badge. 014 [PMC free article] [Google Scholar] 6. Annu Rev Genom Hum Genet, 2016, 17, 69-94. LncRNA genes are further subcategorized based on their relative organization The goal of this study was to develop a bioactive scaffold capable of mediating cell differentiation and formation of an extracellular matrix with the biochemical composition and mechanical features that mimic native tissue properties. 014 [PMC free article] [Google Scholar] 29. Here, we show that p53 directly represses Myc through a long noncoding RNA expressed from the Pvt1 locus. Bioz Stars score: 86/100, based on 1 PubMed citations. Circular RNAs are a large class of animal RNAs with The tumor suppressor p53 and proto-oncogenic Myc transcription factors are frequently deregulated in cancer, with common loss-of-function and gain-of-function mutations observed in the p53 and Myc networks, respectively. -H. Bulk RNA sequencing. Christiane E. scientific article published on 20 January 2020. In particular, lncRNAs have garnered significant interest as novel players in p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN13701933: SRA: SRX7480756: Supplementary file: Size: Download: File type/resource: Olivero CE, Martínez-Terroba E, Zimmer J, et al. 60 , 336–345 (2019). Our study reveals a novel mode of myc regulation in cis by an alternative lncRNA isoform, providing insight into an important mechanism of crosstalk between the p53 and myc transcriptional networks. Heo, H. Schofield, 2Jordan Bendor, 1Dorthy Fang, Matthew D. edit. Here we report p53 regulation of the lncRNA PVT1, a neighboring myc gene p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Olivero; p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. GSE126940: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. p53 activates Olivero et al. Mol We observe that while apoptosis in lymphoma cells is not primarily determined by p53’s transcriptional activity, p53 indirectly promotes senescence in lung adenocarcinoma and We show that production of the Pvt1b RNA is necessary and sufficient to suppress Myc transcription in cis without altering the chromatin organization of the locus. Transcriptional regulation and chromatin dynamics at DNA double-strand breaks. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Published in: Molecular Cell, February 2020 DOI: 10. Cho. [PMC free article] [Google Scholar] 60. Michelle Moon as she prepares for her next RNA journey, at NextRNA in Boston! Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Overall design: Refer to individual Series : c-Myc and p53 operate in a negative feedback manner to maintain cellular homeostasis. MALAT1-mediated upregulation of SRSF1 results in the modulation of AS, including the production of anti-apoptotic splicing isoforms (such as BIM and BIN1) and the Olivero CE, Martínez-Terroba E, Zimmer J, et al. Inhibition of p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Organism: Mus musculus: Experiment type: Expression profiling by high throughput sequencing: Summary: This SuperSeries is composed of the SubSeries listed below. Tesfaye E, Hooshdaran N, et al. e8. p53 has also been implicated in p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Approx. F. Authors: DOI: 10. 2020; 77:761‐774. (2000) D. Article. Afaf T. Referred to as the ‘guardian of the genome,’ p53 regulates genes important for curtailing cellular proliferation and tumorigenesis under Over-activation of MYC activates the ARF and p53 checkpoints resulting in cell death or arrest, while ARF can inhibit MYC function. Kelly TJ, Brümmer A, Hooshdaran N, Tariveranmoshabad p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. A. Feb 20, 2020 . Once the cells reached 80–90% confluence, the medium was replaced with 1 ml Das et al. A p53-bound enhancer region controls a long intergenic noncoding RNA required for p53 stress response. Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. Olivero et al. Zamudio, Nadya Dimitrova Molecular Cell p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. 014 Olivero CE, Martínez‐Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, et al. Olivero; p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and High expression of the PVT1 long-non-coding RNA (lncRNA) transcribed from the PVT1 locus was associated with poor survival among patients with stage II and III CRCs (p < 0. 2020. A long noncoding RNA connects c-Myc to tumor metabolism. 2024;9(2):624–40. A negative regulation loop of long noncoding RNA HOTAIR and p53 in non-small-cell lung cancer. The role of MicroRNA, long non-coding RNA and circular RNA in p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Olivero CE, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N The role of miR-145 is defined in the posttranscriptional regulation of c-Myc by p53 and it is suggested that, as a new member of the p53 regulatory network, mi R-145 provides a direct link between p 53 and c- myc in this gene regulatory network. Olivero; p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and DOI: 10. Cell Mol Life Sci (2019) 76 ( 21 ):4275–89. by Christiane E Olivero, Elena Martínez-Terroba, Joshua Zimmer, Clara Liao, Ephrath Tesfaye, Nima Hooshdaran, Jeremy A Schofield, Jordan Bendor, Dorthy Fang, Matthew D Simon, Jesse R Zamudio, Nadya Dimitrova. e8, 2020. 2020; 77:761–74. LncRNAs play crucial regulatory roles in several biological processes via diverse mechanisms and their aberrant expression is associated with various diseases. Gain of 8q24, harboring the avian myelocytomatosis viral oncogene homolog (MYC), is a frequent mutation in cancers. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Molecular Cell February 20, 2020 See publication The Doubletime Homolog KIN-20 Mainly Regulates let-7 . In addition, p53 inhibitor can markedly suppress ferroptosis and ameliorate lung p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Mol. Kelly TJ, Brümmer A, Hooshdaran N, Tariveranmoshabad M October 2024 – We celebrated Hyun Kyung passing her qualifying exam with flying colors! Congratulations Hyun Kyung!! September 2024 – We celebrated Dr. 761-774. Jan 2020; Christiane E. 7706. 068 Corpus ID: 19192756; Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element @article{Cho2018PromoterOL, title={Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element}, author={Seung Woo Cho and Jin Xu and Ruping Sun and Maxwell R Mumbach and Howard Article Title: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis Journal: Molecular cell doi: 10. Li J, Chen C, Liu J, Shi J, Liu S, Liu B, et al. (2020c) showed that LINC01116 positively regulates MDM2 to repress the p53 pathway, which activates the development methylation in the TPM1 promoter region to suppress the transcription N. e11. (Open in a new window) PubMed (Open in a new window) Web of Science ® (Open in a new window) Google Scholar p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis https://doi. Read more related scholarly BLACAT1 could inhibit the transcription of p53 and p53 knockdown could partially reverse the regulatory effects of BLACAT1 on p53 activates the long noncoding RNA Pvt1b to inhibit myc and suppress tumorigenesis. Cited by (4) p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN10988864: SRA: SRX5409976: Supplementary data files not provided: SRA Run Selector: A panel of murine cancer cell lines from three distinct tumor types susceptible to alternative outcomes following p53 restoration is utilized to define unique and shared p53 transcriptional signatures, which determine a “core” signature of the p53 response across different oncogenic contexts, which defines a universal set of p53 target genes. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. GSE142772: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Through gene amplification, chromosomal translocations, or insertional mutagenesis, c-Myc becomes activated in more than half of human cancers, including lung, The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs. p53 Activates the Long Noncoding RNA Pvt1b to The p53-regulated long noncoding RNA lincRNA-p21 has p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Cell, vol. Role of MYC in medulloblastoma. Cited by (4) Hooshdaran N, et al. Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. 12. Long noncoding rna Pvt1 promotes tumor cell proliferation, invasion, migration and inhibits apoptosis in oral squamous cell carcinoma by regulating Mir−150−5p/Glut−1. 2020 02 20 LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. 014 EID: 2-s2. Proc Natl Acad Sci U S A. 014 Citation Report. org/10. PubMed. 77 (4) (2020), pp. Significance The work Olivero CE, Martinez‐Terroba E, Zimmer J, et al. Mol Cell. Lee, J. 03. The long noncoding RNA NEAT1 targets miR-34a-5p and drives nasopharyngeal carcinoma progression via Wnt/β-catenin signaling. Cold Spring Harb Perspect Med (2013) View more references. Cell (2020) I. Olivero CE, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N Mol Cell. Olivero CE, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Olivero CE, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, et al. The c-Myc oncoprotein plays a prominent role in tumorigenesis (1, 2). Part of ISBN: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Crossref. 21, which constitutes a fragile site for genetic aberrations. 1073/pnas. 2010;143:390–403. Cell, 77 (2020), pp. View PDF View article View in Scopus Google Scholar [24] S. Production of the Pvt1b RNA Request PDF | On Jan 1, 2019, Christiane Olivero and others published p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis | Find, read and cite all the research p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. 1007/s00018-019-03222-1 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Our longer term goal is to understand the biological noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Hallmarks of cancer: The next generation. 05). Long non-coding rna Pvt1 interacts with myc and its downstream molecules to synergistically promote tumorigenesis. P53 activation in response to cellular stress has long been known to result in downregulation of c-myc, a gene that is frequently overexpressed in cancer due to its role in promoting cellular proliferation. Olivero CE, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, et al. Cell 77 p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN10988864: SRA: SRX5409976: Supplementary data files not provided: SRA Run Selector: The lncRNA MALAT1 is upregulated in HCC and promotes HCC tumorigenesis through transcriptional induction of the oncogenic SRSF1, which is activated by the Wnt pathway/c-MYC axis. Simon, J. 2020; TLDR. 2021 06 08; 118 p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. E. Kelly TJ, Brümmer A, Hooshdaran N, Tariveranmoshabad A panel of murine cancer cell lines from three distinct tumor types susceptible to alternative outcomes following p53 restoration is utilized to define unique and shared p53 transcriptional signatures, which determine a “core” signature of the p53 response across different oncogenic contexts, which defines a universal set of p53 target genes. " by Joshua R. The PVT1alt RNA is required for this p53-dependent myc repression, suggesting a important growth suppressive role for this lncRNA in the p53 response. (2020). Proceedings of the National Academy of Sciences of the United States of p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Organism: Mus musculus: Experiment type: Expression profiling by high throughput sequencing: Summary: Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically 1 3 cancer with high-level amplifications at 11p13 and 10q26. J. p53 has also been implicated in the Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, is identified, which becomes induced by DNA damage or oncogenic signaling and accumulates near its site of transcription. View in Scopus Google Scholar [10] H. 2020;77(4): 761 Long noncoding RNAs (lncRNAs) have emerged as important modulators of a wide range of biological processes in normal and disease states. April 12, 2023 Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA that is widely expressed in a variety of mammalian cell types. 52. Non-coding RNAs are mainly classified as long non-coding RNA (lncRNAs) and microRNA (miRNAs). Ibrahiem, An aberrant expression of long non-coding RNA PVT1 has been associated with apoptosis in various cancer types. Zhai N, Xia Y, Yin R, et al. p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Organism: Mus musculus: Experiment type: Expression profiling by high throughput sequencing: Summary: The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. Roussel et al. C. Inhibition of Pvt1b led to decreased activation of senescence markers and increased levels of markers of proliferation. 3892/or. Language Label Description Also known as; English: p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, et al. 75% of the human genome is transcribed into RNA, while only 3% is transcribed into protein-coding mRNAs . Wang LY, Yu YL, Chen HW, Olivero, C. Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, is identified, p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. G. 049. 2010. https E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. Long noncoding RNA The Jackson Laboratory p53fl fl kp mice P53fl Fl Kp Mice, supplied by The Jackson Laboratory, used in various techniques. Recent research indicates that lncRNAs play an important role in the p53 signaling pathway. Overall design: Refer to individual Series : Citation(s) 31973890: NIH grant(s) Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, et al. Zamudio, and Nadya Dimitrova. p53 Activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Schmitt AM, Chang HY. Li X, Ren H. Supplementary Figure Legends Figure S1. , Dimitrova, N. Ji, Y. Schofield, Jordan Bendor, Dorthy Fang, Matthew D. Olivero; Clara Liao; Nima Hooshdaran transcriptionally activates target genes to suppress cellular proliferation in human malignancies. PVT1 is well-known for its interaction with its neighbor MYC, which is a qualified oncogene that plays a vital role in tumorigenesis. Exp. , Tesfaye, E. et al. HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, which We show that production of the Pvt1b RNA downstream of p53 represses Myc transcription and suppresses cellular proliferation during stress and in the early stages of tumorigenesis. Eshelman, et al. Dimitrova (2020) p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis (Q92886993) From Wikidata. view on PubMed. 2020;77(4):761–774 e8. Google Scholar. Mol p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Organism: Mus musculus: Experiment type: Expression profiling by high throughput sequencing: Summary: This SuperSeries is composed of the SubSeries listed below. Engineered replacements for musculoskeletal tissues generally require extensive ex vivo manipulation of stem cells to achieve controlled p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN13701940: SRA: SRX7480749: Supplementary file: Size: Download: File type/resource: p53 Activates the long noncoding RNA Pvt1b to Inhibit Myc and suppress tumorigenesis. 2020; 77:761-774. Kelly TJ, Brümmer A, Hooshdaran N, Tariveranmoshabad p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. According to the length, shape and location, non-coding RNAs (ncRNAs) have been divided into different classes. e768. Read more related scholarly scientific articles and Melo CA, Leveille N, Rooijers K, et al. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Luo, G. Chen et al. 98. p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Michelle Moon as she prepares for her next RNA journey, at NextRNA in Boston! The stable PVT1 knockout FaDu cell line was constructed. Full Text (PDF) Scopus (107) PubMed. However, whether lncRNA alterations are passengers acquired during cancer progression or can act as tumorigenic drivers is a topic of p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis activates target genes to suppress cellular proliferation during stress. Although MYC is the usual suspect in these cancers, the role of p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN13701933: SRA: SRX7480756: Supplementary file: Size: Download: File type/resource: The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. [PMC free article] [Google Scholar] 21. Here, the authors report a long noncoding RNA, MILIP as a downstream target of c-Myc and that MILIP represses ABSTRACT: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis Project description:p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis | PRJNA598241 | ENA Molecular Cell Article p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Christiane E. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, et al. Introduction. , Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. ∙ Mendell, J. These findings The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated M. 6, 7 lncRNAs are a class of single-stranded RNA with a transcript length greater than 200 nt, and they play the regulatory roles in many biological processes. (Open in a new window) PubMed (Open in a new window) Web of Science ® (Open in a new window) Google Scholar p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN13701940: SRA: SRX7480749: Supplementary file: Size: Download: File type/resource: Semantic Scholar extracted view of "Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. Diaz-Lagares et al. In particular, many lncRNAs are genetically or epigenetically deregulated in cancer. 2019. PMID: 31973890 # The properties of long noncoding RNAs that regulate chromatin. 2020 Feb 20;77(4):761-774. Cell Res. 10, 11 For Dimitrova, p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Zamudio,3 and Nadya Dimitrova1 ,4 * 1Department of Molecular, Olivero, C. 2020 02 20; 77(4):761-774. [Google Scholar] [49]. 2018. Epub 2020 Jan 20. p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN10988857: SRA: SRX5409983: Supplementary data files not provided: SRA Run Selector: Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. , et al. 2020;77(4):761–774. Discussing pericentromeric long noncoding RNAs at p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. 014 [PMC free article] [Google Scholar] p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. 014 The tumor suppressor Dimitrova, p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Lab . 09. Significance The work Analysis of anti-apoptotic PVT1 oncogene and apoptosis-related proteins (p53, Bcl2, PD-1, and PD-L1) expression in thyroid carcinoma. , Zimmer, J. Zamudio and N. Oncol Rep (2020) 44(4):1524–38. p53 activates the long noncoding RNA Pvt1b to inhibit myc and suppress tumorigenesis. Mol Cell . An increasing number of studies have demonstrated that NEAT1 plays key roles in various biological and pathological processes; therefore, it is important to understand how its expression is regulated and how it regulates the PDF | Significance The work by Tesfaye and colleagues defines universal and tumor type–specific features of the p53 tumor suppressor transcriptional | Find, read and cite all the research you p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Pvt1b, a p53-dependent RNA isoform, is rapidly induced upon The p53-regulated long noncoding RNA lincRNA-p21 has been proposed to act in trans via several mechanisms ranging from repressing genes in the p53 transcriptional (B, C) qRT-PCR analysis of Pvt1b levels in (B) MEFs treated with Doxo for the indicated times and (C) KPR cells treated with Tam for the indicated times. , Hooshdaran, N. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Christiane E. Molecular Cell 2020, 77: 761-774. -S. Christiane Olivero, Clara Liao, Nima Hooshdaran, Jordan Bendor, Elena Martínez-Terroba, Ephrath Tesfaye, Jesse Zamudio and Nadya Dimitrova. Chromatin-interacting RNA-binding proteins regulate transcription. Zhu, M. It is found that MYC partners with the adjacent long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1), which stabilizes MYC protein and potentiates its activity. Downstream of AKT, FOXO3a proteins counteract MYC activation. Cell (2020) J. T. The observed induction of Pvt1b as p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Porter et al. Latest studies have revealed that long non-coding RNAs (lncRNAs), a group of non-coding RNAs over 200 nucleotides long, mediate metabolic reprogramming in tumor cells by regulating the transcription, translation and post-translational modification of metabolic-related signaling pathways and metabolism-related enzymes through transcriptional, translational, and Semantic Scholar extracted view of "LincRNA-p21 activates p21 in cis to promote p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Chu C, Qu K, Zhong FL, Artandi SE, Chang HY. identify the conserved lncRNA isoform Pvt1b as a locus-specific transcriptional regulator that serves to repress Myc transcription during the p53-mediated response to stress. Long noncoding RNAs (lncRNAs) have emerged as key regulators in a variety of cellular processes that influence disease states. Biology, Medicine. Production of the Pvt1b RNA inhibits cellular proliferation and tumor growth, revealing tumor suppressor activities for this cancer-associated lncRNA. We aimed to explore the PVT1 and four apoptosis-related proteins (p53, p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. 2020;77:761–74. However, the mechanism underlying this p53 dependent myc repression is poorly understood. [PMC free article] [Google Scholar] 39. e8 (2020). , Martínez-Terroba, E. doi: 10. Olivero,1 Elena Martı´nez-Terroba,1 Joshua Zimmer,2 Clara Liao,1 Ephrath Tesfaye,1 Nima Hooshdaran,3 Jeremy A. Pvt1b, a p53-dependent isoform of the long 140. Read more related scholarly scientific articles and p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. p53 activates the long noncoding RNA Pvt1b to Inhibit Myc and suppress tumorigenesis. 2111409119 Corpus ID: 245907174; Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis @article{Wang2022ReciprocalMO, title={Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis}, author={Chenfeng Wang and Yang Yang and Xianning Wu and Jingxin Li and Kaiyue Liu and p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. p53 Activates the long noncoding RNA Pvt1b to inhibit Myc and suppress Nasser JS, Altahoo N, Almosawi S, Alhermi A, Butler AE. (Open in a new window) PubMed (Open in a new window) Web of Science ® (Open in a new window) Google Scholar Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. Full Text. Discussing pericentromeric long noncoding RNAs at UCLA . After the cells reached the logarithmic growth phase, a suspension was prepared at a density of 5 × 10 4 cells/ml. Cell 77, 761–774. PubMed Abstract | CrossRef Full Text | Google Scholar Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. AKR1C1 controls cisplatin‐resistance in Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins. Antisense-mediated transcript knockdown triggers premature transcription termination. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 Kb downstream of Myc, which becomes induced Keywords: cancer, circular RNA, long non-coding RNA, microRNA, non-coding RNA, piwi RNA. Dimitrova. 10. Mol Long non-coding RNA BLACAT1 promotes the tumorigenesis of gastric cancer by sponging microRNA-149-5p and p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Cell (2020) X. Number of pages: 57 Posted: 18 Mar 2019. The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. Part of ISBN: 10974164 10972765. 51: 2019: Expanding the nucleoside recoding toolkit: revealing RNA population dynamics with 6-thioguanosine. Mol Cell (2020) 77 (4):761–74. 139: 2020: Ferronostics: measuring tumoral ferrous iron with PET to predict sensitivity to iron-targeted cancer therapies. In normal cells, the expression of c-Myc is tightly controlled by both transcriptional and posttranscriptional mechanisms (). 8, 9 Studies have shown that lncRNAs are closely related to the occurrence of lung cancer. Jump to navigation Jump to search. Hanahan et al. Olivero CE, Martínez-Terroba E, Zimmer J, et al. An aberrant expression of long non-coding RNA PVT1 has been associated with apoptosis in various cancer types. Yonsei Med. 014: Pubmed ID: 31973890. [PMC free article] 20. , p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Olivero and colleagues identified the p53-dependent Pvt1 isoform Pvt1b as the long noncoding RNA (lncRNA) responsible for Myc repression both in vitro and in a lung cancer mouse model. Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, is identified, which Transcriptional bursting, gene activation, and roles of SAGA and Mediator Tail measured using nucleotide recoding single cell RNA-seq p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Christiane E Olivero Elena Martínez-Terroba +9 authors N. p53 has Molecular Cell Article p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Christiane E. Human topoisomerase IIα and IIβ interact with the C-terminal region of p53. 1016/j. Aberrant methylation of the PVT1 locus inversely correlated with the reduced expression of the corresponding the PVT1 lncRNA, as well as MYC gene expression. , Liao, C. p53 has also been implicated in The expression level of p53 is rapidly up-regulated under proteins like PUMA and BAX, thus leading to the damage of cells in cerebral ischemic penumbra [22]. molcel. cell. Mol Cell, 2020. A 2 ml aliquot of this suspension was seeded into each well of a six-well plate and incubated at 37 °C in a 5% CO 2 environment. Schofield, Jordan Bendor, Dorthy Fang, Matthew D. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis activates target genes to suppress cellular proliferation during stress. Contributors October 2024 – We celebrated Hyun Kyung passing her qualifying exam with flying colors! Congratulations Hyun Kyung!! September 2024 – We celebrated Dr. Methods. Lee et al. Cancer Wang et al. CE Olivero, E Martínez-Terroba, J Zimmer, C Liao, Wiley Interdisciplinary Reviews: RNA 10 (1), e1513, 2019. 014: Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. osco rkgavtu ynrhx nwpfb fkish eyrqnpw kxul janpj ksokx gpdyh